ABELCET® (Amphotericin B Lipid Complex Injection) 100 mg
ثبت نشده
چکیده
DESCRIPTION ABELCET is a sterile, pyrogen-free suspension for intravenous infusion. ABELCET consists of amphotericin B complexed with two phospholipids in a 1:1 drug-to-lipid molar ratio. The two phospholipids, l-α-dimyristoylphosphatidylcholine (DMPC) and l-α-dimyristoylphosphatidylglycerol (DMPG), are present in a 7:3 molar ratio. ABELCET is yellow and opaque in appearance, with a pH of 5 7. NOTE: Liposomal encapsulation or incorporation in a lipid complex can substantially affect a drug’s functional properties relative to those of the unencapsulated or nonlipid-associated drug. In addition, different liposomal or lipid-complexed products with a common active ingredient may vary from one another in the chemical compos ition and phys ical form of the lipid component. Such differences may affect functional properties of these drug products . Amphotericin B is a polyene, antifungal antibiotic produced from a strain of Streptomyces nodosus. Amphotericin B is designated chemically as [1R-(1R*, 3S*, 5R*, 6R*, 9R*, 11R*, 15S*, 16R*, 17R*, 18S*, 19E, 21E, 23E, 25E, 27E, 29E, 31E, 33R*, 35S*, 36R*, 37S*)]-33-[(3-Amino-3, 6-dideoxyβ-Dmannopyranosyl) oxy]-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39dioxabicyclo[33.3.1] nonatriaconta-19, 21, 23, 25, 27, 29, 31-heptaene-36-carboxylic acid. It has a molecular weight of 924.09 and a molecular formula of C H NO . The structural formula is:
منابع مشابه
Study of the toxicity of a new lipid complex formulation of amphotericin B.
OBJECTIVES The aim of this study was to evaluate the toxicity of a new lipid complex formulation of amphotericin B (LC-AmB) produced by a simple process. METHODS Toxicity was evaluated after daily administration for 21 consecutive days in female CD1 mice. Doses of LC-AmB up to 20 mg/kg were used, and compared with Fungizone at 0.5 mg/kg and Abelcet at 10 mg/kg. Acute toxicity after a single b...
متن کاملEfficacy of Abelcet alone, or in combination therapy, against experimental central nervous system aspergillosis.
BACKGROUND CNS aspergillosis is the most frequent and devastating manifestation of dissemination and mortality is high. METHODS Cyclophosphamide-suppressed CD-1 mice were infected intracerebrally with conidia of Aspergillus fumigatus and treated for 10 days with suboptimal doses of Abelcet (4 mg/kg) plus micafungin (1 mg/kg), caspofungin (1 mg/kg), itraconazole (100 mg/kg) or voriconazole (40...
متن کاملPharmacokinetic profile of ABELCET (amphotericin B lipid complex injection): combined experience from phase I and phase II studies.
Amphotericin B (AmB) has been the most effective systemic antifungal agent, but its use is limited by the dose-limiting toxicity of the conventional micellar dispersion formulation (Fungizone). New formulations with better and improved safety profiles are being developed and include ABELCET (formerly ABLC), but their dispositions have not been well characterized; hence, the reason for their imp...
متن کاملCase Report: Treatment of Kala-Azar by Amphotericin B Lipid Complex (ABELCET)
A 45 year-old female was admitted to Department of Infectious Diseases of Social Security Hospital, Tepecik, İzmir. She was found to have hepatosplenomegaly; pancytopenia and hypergammaglobulinemia during physical and laboratory examinations. Leishmania amastigotes were seen in the bone marrow smears and serological and bacteriological tests were all found to be positive. The patient was given ...
متن کاملAmphotericin B Formulations and Other Drugs for Visceral Leishmaniasis
Visceral leishmaniasis (VL), which is endemic in the Indian subcontinent (42,623 reported cases/year of which 34,918 were in India), the Mediterranian region (875 cases/year), East Africa (8,569 cases/year), and Brazil (3,481 cases/year) has undergone a revolution in chemotherapy in the last 15 years. Treatment had been with the classical agents pentavalent antimony and amphotericin B deoxychol...
متن کامل